Research Projects

Chaulagain S, Liu JA, McCombs JE, Klein SL. Sex differences in immune responses to viruses, bacteria and vaccines. Nat Immunol. 2026 Apr;27(4):660-673. https://doi.org/10.1038/s41590-026-0247(https://doi.org/10.1038/s41590-026-0247) Yoshida Y, Zu Y, Aguilar D, Ferdinand KC, Fonseca VA. Cumulative effect of hyperglycemia and insulin resistance on cardiac dysfunction: The coronary artery risk development in young adults (CARDIA) study. Am Heart J. 2026 Feb;292:107276. https://doi.org/10.1016/j.ahj.2025.09.008(https://doi.org/10.1016/j.ahj.2025.09.008) Lovre D, Zu Y, Cheung HY, Yoshida Y. Life's essential 8 and risk of progression to diabetes among young adults with prediabetes. Sci Rep. 2025 Oct 13;15(1):35690. https://doi.org/10.1038/s41598-025-19472-y(https://doi.org/10.1038/s41598-025-19472-y) Yoshida Y, Li D, Li X, Rohatgi A, Bazzano L, Fonseca VA, Qi L, Mauvais-Jarvis F. Greater alterations in atherogenic lipids and inflammatory markers in women during type 2 diabetes development and risk of coronary heart disease-Findings from two population-based studies. J Clin Lipidol. 2025 Sep-Oct;19(5):1385-1394. https://doi.org/10.1016/j.jacl.2025.08.010(https://doi.org/10.1016/j.jacl.2025.08.010) Martier AT, Maurice YV, Conrad KM, Carlino DA, Mauvais-Jarvis F, Mondrinos MJ. Estradiol and Dihydrotestosterone Exert Sex-specific Effects on Human Fibroblast and Endothelial Proliferation, Bioenergetics, and Vasculogenesis. Commun Biol. 2025 Oct 3;8(1):1422. PMID: 41044405 Martier A, Kpeli G, Boone K, Posey IR, Mondrinos MJ. Fetal Bovine Serum Modulates Primary Human Cell Phenotypes, Endothelial Barrier Function, Vasculogenesis, and Angiogenesis in a Sex-Specific Manner. Cellular and Molecular Bioengineering. 2025 September. https://doi.org/10.1038/s42003-025-08822-1(https://doi.org/10.1038/s42003-025-08822-1) Wu X, Zu Y, Wang X, Yoshida Y. Loneliness, Social Isolation and Stroke Risk in Men and Women with and without Diabetes. BMC Public Health. 2025 Sep 25;25(1):3135. https://doi.org/10.1186/s12889-025-24458-6(https://doi.org/10.1186/s12889-025-24458-6) Yoshida Y, Nguyen NQ, Moon EH, Rebholz C, Skali H, Arthur V, Echouffo-Tcheugui JB, Ballantyne C, Selvin E, Shah A, Kaplan R, Rodriguez CJ, Qi Q, Cheng S, Yu B. A Metabolomics Study of Cardiac Dysfunction in Hyperglycemia: Findings from the Atherosclerosis Risk in Communities (ARIC) Study and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Diabetes Care. 2025 Sep 1;48(9):1589-1597. https://doi.org/10.2337/dc25-0730(https://doi.org/10.2337/dc25-0730) Kuo S, Li D, Wargny M, Yoshida T, Yoshida Y. Blood Metabolome of Cardiovascular Disease, Diabetic Kidney Disease, and Diabetic Retinopathy in Type 2 Diabetes Patients: A Systematic Review and Meta-analysis. Endocr Res. 2025 Aug 20;:1-27. https://doi.org/10.1080/07435800.2025.2545832(https://doi.org/10.1080/07435800.2025.2545832) You Lu ,Yilin Yoshida. Trends and Risk Factors of Oral Health and Preventive Dental Care in Adults With Diabetes and Prediabetes: National Health and Nutrition Examination Survey 1999-2000 to 2017-2020. Endocr Pract. 2025; 25:S1530-891X(25)00128-4. https://doi.org/10.1016/j.eprac.2025.04.010(https://doi.org/10.1016/j.eprac.2025.04.010) Xiu Wu, Yuanhao Zu, Danting Li, Yilin Yoshida. Psychosocial and Behavioral Risk Patterns and Risk of Cardiovascular Complications in People with Type 2 Diabetes. Diabetes Res Clin Pract. 2025; 221:112037. https://doi.org/10.1016/j.diabres.2025.112037(https://doi.org/10.1016/j.diabres.2025.112037) Yilin Yoshida, Yuanhao Zu, Bingbing Fan, Shengxu Li, Tadashi Yoshida, Emily Harville, Tao Zhang, Sejong Bae, James Shikany, Vivian A. Fonseca . Cumulative Effect of Metabolic Risk Factors on Left Ventricular Geometry in Those with Versus without Early-onset Type 2 Diabetes or Prediabetes: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Diabetes Obes Metab. 2024; 26(8): 3392-3402. https://doi.org/10.1111/dom.15681(https://doi.org/10.1111/dom.15681)

Mark Mondrinos. Sex-Specific Actions of Estradiol and Dihydrotestosterone in Primary Human Cell Cultures and Microphysiological Systems. Endocrine Society 2025, San Francisco, CA. July 2025 Mark Mondrinos. Capturing Sex-Specificity in Microphysiological Models of Diabetic Retinopathy and Lung Cancer. Microphysiological Systems (MPS) World Summit 2025, Brussels, Belgium. June 2025 Yoshida Y, Li D, Li X, Fonseca AV, Qi L, Mauvais-Jarvis F. Sex Differences in Metabolomics and Risk of Coronary Heart Disease in Type 2 Diabetes – Findings from the UK Biobank Study. American Diabetes Association Annual Meeting, Orlando, FL. June 2025 Yoshida Y, Nguyen NQH, Moon EH, Mauvais-Jarvis F, Fonseca V, Yoshida T, Rebholz C, Skali H, Arthur V, Echouffo-Tcheugui J, Ballantyne C, Selvin E, Shah A, and Yu B. A Metabolomic Study of Cardiac Dysfunction in Hyperglycemia. AHA Epidemiology and Lifestyle, New Orleans, March 2025 Wu X, Li D, Zu Y, Yoshida Y. Psychosocial and behavioral Risk Patterns and Risk of Cardiovascular Complications in People with Type 2 Diabetes. AHA Epidemiology and Lifestyle, New Orleans, March 2025 Lovre D, Zu Y, Yoshida Y. Life Essential 8 Is Associated with A Lower Risk Of Progression To Type 2 Diabetes. AHA Epidemiology and Lifestyle, New Orleans, March 2025 Yoshida Y and Li D. Triglycerides Contribute to Women’s Excess Cardiovascular Risk in Type 2 Diabetes. Southern Regional Meeting, New Orleans, LA. February 2025. Wu X, Zhang B, Zhang J, Yoshida Y. Disentangling the Effects of Various Risk Factors and Trends in Lung Cancer Mortality. Southern Regional Meeting, New Orleans, LA. February 2025 Yilin Yoshida, Sydney Kuo, Danting Li, Amy Corder, Matthieu Wargny, Tadashi Yoshida. 6720 Metabolomics And Risk Of Vascular Complications In Type 2 Diabetes - A Systematic Review and Meta-Analysis. Journal of the Endocrine Society, Volume 8, Issue Supplement_1, October-November 2024. https://doi.org/10.1210/jendso/bvae163.846(https://doi.org/10.1210/jendso/bvae163.846) Yilin Yoshida, Danting Li, Xiang Li, Vivian Fonseca, Franck Mauvais-Jarvis, Lu Qi. 152-OR: Sex Differences in Metabolomics and Risk of Coronary Heart Disease in Type 2 Diabetes. Diabetes 14 June 2024; 73 (Supplement_1): 152–OR. https://doi.org/10.2337/db24-152-OR(https://doi.org/10.2337/db24-152-OR) Yilin Yoshida, Keith C. Ferdinand, David Aguilar, Vivian Fonseca. 1269-P: Cumulative Effect of Early-Onset Type 2 Diabetes on Cardiac Dysfunction—The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Diabetes 14 June 2024; 73 (Supplement_1): 1269–P. https://doi.org/10.2337/db24-1269-P(https://doi.org/10.2337/db24-1269-P) Janet McCombs. The Future of mRNA Vaccines for Infectious Diseases and Cancer Immunotherapy. American Thoracic Society International Meeting, San Diego, CA. May 2024 Mark J. Mondrinos. Sex-specific Effects of Dihydrotestosterone and Estradiol in Cultured Human Cells and 3D Tissue Models. Androgen Society Annual Meeting. Boston, MA. May 2024 Mark J. Mondrinos. Engineering Sex-specific in vitro Culture Systems. American Chemical Society, ACS-BIOT 2024. New Orleans, LA. March 2024